Neurobiology of Disease Depression of Synaptic Transmission by Vascular Endothelial Growth Factor in Adult Rat Hippocampus and Evidence for Increased Efficacy after Chronic Seizures
نویسندگان
چکیده
Daniel P. McCloskey,1 Susan D. Croll,2,3,4 and Helen E. Scharfman1,5 1Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993, 2Department of Psychology, and Neuropsychology and Neuroscience Doctoral Subprograms, Queens College, Flushing, New York 11367, 3Graduate Center of City University of New York, New York, New York 10016, 4Regeneron Pharmaceuticals, Tarrytown, New York 10591, and 5Departments of Pharmacology and Neurology, Columbia University, College of Physicians and Surgeons, New York, New York 10032
منابع مشابه
Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures.
In addition to its potent effects on vasculature, it has become clear that vascular endothelial growth factor (VEGF) has effects on both neurons and glia, and recent studies suggest that it can be neuroprotective. To determine potential mechanisms underlying this neuroprotection, recombinant human VEGF was bath applied to adult rat hippocampal slices, and both extracellular and intracellular re...
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